Latent tuberculosis: risk factors, screening and treatment in liver transplantation recipients from an endemic area.
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Patients undergoing solid organ transplantation, particularly those who live or have lived in tuberculosis (TB) endemic areas, are at a high risk of developing TB. The majority of post-transplantation TB cases are associated with reactivation of latent TB infection (LTBI). Brazil is in a single position with overlapping areas of high TB endemicity and high transplant activity. In liver transplant (LT), one should be aware of the potential hepatotoxicity associated with the treatment regimens for LTBI.AIMTo evaluate the frequency of LTBI in LT patients and treatment-related issues.METHODS This was a retrospective analysis of a cohort of cirrhotic patients aged ≥ 18 years, who underwent LT at a high-complexity teaching hospital from January 2005 to December 2012.RESULTS
Overall, 429 patients underwent LT during the study period. Of these, 213 (49.7%) underwent the tuberculin skin test (TST) during the pre-transplant period, and 35 (16.4%) of them had a positive result. The treatment for LTBI was initiated after LT in 12 (34.3%) of the TST-positive patients; in 3 (25.0%), treatment was maintained for at least 6 mo.CONCLUSIONThe prevalence of LTBI was lower than expected. Initiation and completion of LTBI treatment was limited by difficulties in the management of these special patients
Abstract
Assunto
Tuberculose Latente, Tuberculose, Infeccção, Transplante de orgãos, Fatores de risco
Palavras-chave
Latent tuberculosis, Liver transportation, Tuberculosis, Infection, Transplatation, Risk factors
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https://www.wjgnet.com/2220-3230/full/v11/i12/512.htm