Latent tuberculosis: risk factors, screening and treatment in liver transplantation recipients from an endemic area.

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dc.creatorIsabela Dias Lauar
dc.creatorLuciana Costa Faria
dc.creatorRoberta Maia de Castro Romanelli
dc.creatorWanessa Trindade Clemente
dc.date.accessioned2023-07-04T20:34:10Z
dc.date.accessioned2025-09-09T00:41:13Z
dc.date.available2023-07-04T20:34:10Z
dc.date.issued2021-12-18
dc.format.mimetypepdf
dc.identifier.doi10.5500/wjt.v11.i12.512
dc.identifier.issn22203230
dc.identifier.urihttps://hdl.handle.net/1843/55779
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofWorld Journal of Transplantation
dc.rightsAcesso Aberto
dc.subjectTuberculose Latente
dc.subjectTuberculose
dc.subjectInfeccção
dc.subjectTransplante de orgãos
dc.subjectFatores de risco
dc.subject.otherLatent tuberculosis
dc.subject.otherLiver transportation
dc.subject.otherTuberculosis
dc.subject.otherInfection
dc.subject.otherTransplatation
dc.subject.otherRisk factors
dc.titleLatent tuberculosis: risk factors, screening and treatment in liver transplantation recipients from an endemic area.
dc.typeArtigo de periódico
local.citation.epage522
local.citation.issue12
local.citation.spage512
local.citation.volume11
local.description.resumoPatients undergoing solid organ transplantation, particularly those who live or have lived in tuberculosis (TB) endemic areas, are at a high risk of developing TB. The majority of post-transplantation TB cases are associated with reactivation of latent TB infection (LTBI). Brazil is in a single position with overlapping areas of high TB endemicity and high transplant activity. In liver transplant (LT), one should be aware of the potential hepatotoxicity associated with the treatment regimens for LTBI.AIMTo evaluate the frequency of LTBI in LT patients and treatment-related issues.METHODS This was a retrospective analysis of a cohort of cirrhotic patients aged ≥ 18 years, who underwent LT at a high-complexity teaching hospital from January 2005 to December 2012.RESULTS Overall, 429 patients underwent LT during the study period. Of these, 213 (49.7%) underwent the tuberculin skin test (TST) during the pre-transplant period, and 35 (16.4%) of them had a positive result. The treatment for LTBI was initiated after LT in 12 (34.3%) of the TST-positive patients; in 3 (25.0%), treatment was maintained for at least 6 mo.CONCLUSIONThe prevalence of LTBI was lower than expected. Initiation and completion of LTBI treatment was limited by difficulties in the management of these special patients
local.identifier.orcidhttps://orcid.org/0000-0003-0848-3740
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://www.wjgnet.com/2220-3230/full/v11/i12/512.htm

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