COtab: expedient and safe setup for Pd-catalyzed carbonylation chemistry
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Bench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib.
Abstract
Assunto
Catalisadores, Compostos de carbono, Comportos inorgânicos, Óxidos, Testes químicos e reagentes, Agentes antineoplásicos
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Carbonylation, Catalysts, Inorganic carbon compounds, Oxides, Reagents
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https://pubs.acs.org/doi/10.1021/acs.orglett.9b01423