COtab: expedient and safe setup for Pd-catalyzed carbonylation chemistry

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dc.creatorHugo Paul Collin
dc.creatorWallace Junio Reis
dc.creatorDennis Ulsøe Nielsen
dc.creatorAnders Thyboe Lindhardt
dc.creatorMarcelo Siqueira Valle
dc.creatorRossimiriam Pereira de Freitas
dc.creatorTroels Skrydstrup
dc.date.accessioned2024-07-30T19:31:10Z
dc.date.accessioned2025-09-09T00:17:12Z
dc.date.available2024-07-30T19:31:10Z
dc.date.issued2019
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1021/acs.orglett.9b01423
dc.identifier.issn1523-7052
dc.identifier.urihttps://hdl.handle.net/1843/72115
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOrganic Letters
dc.rightsAcesso Restrito
dc.subjectCatalisadores
dc.subjectCompostos de carbono
dc.subjectComportos inorgânicos
dc.subjectÓxidos
dc.subjectTestes químicos e reagentes
dc.subjectAgentes antineoplásicos
dc.subject.otherCarbonylation
dc.subject.otherCatalysts
dc.subject.otherInorganic carbon compounds
dc.subject.otherOxides
dc.subject.otherReagents
dc.titleCOtab: expedient and safe setup for Pd-catalyzed carbonylation chemistry
dc.typeArtigo de periódico
local.citation.epage5778
local.citation.issue15
local.citation.spage5775
local.citation.volume21
local.description.resumoBench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib.
local.identifier.orcidhttps://orcid.org/0000-0001-9483-7183
local.identifier.orcidhttps://orcid.org/0000-0001-7337-6488
local.identifier.orcidhttps://orcid.org/0000-0002-4521-5991
local.identifier.orcidhttps://orcid.org/0000-0001-8941-4899
local.identifier.orcidhttps://orcid.org/0000-0002-9759-9915
local.identifier.orcidhttps://orcid.org/0000-0001-6974-3724
local.identifier.orcidhttps://orcid.org/0000-0001-8090-5050
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://pubs.acs.org/doi/10.1021/acs.orglett.9b01423

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