Envolvimento do sistema endocanabinoide nos efeitos da cocaína no modelo de preferência condicionada ao contexto: Uma revisão sistemática e metanálise.

Abstract

Endocannabinoids are lipid mediators that interact with cannabinoid receptors, to which Δ9-tetrahydrocannabinol, the main psychoactive constituent of Cannabis sativa, binds. Cocaine, a psychostimulant drug, acts by inhibiting the reuptake of monoamines and converges on the activation of reward pathways. The endocannabinoid system modulates these pathways and has been studied as a crucial component of this circuit underlying the effect of drugs of abuse. A model frequently used for this purpose is the conditioned place preference (CPP). The present systematic review and meta-analysis aims to elucidate the effects of cannabinoids and the involvement of the endocannabinoid system in responses to cocaine in the CPP model. Seventeen studies were selected through the PICOS eligibility strategy in which the data of interest were extracted to carry out the meta-analysis. The present systematic review and meta-analysis reveals a modest positive trend in the experimental group relative to the control. However, this trend is insufficient to achieve robust statistical significance. Advances in cannabinoid therapies require more studies, especially those that address the molecular mechanisms underlying experimental models for studying SUD.