Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: a critical review
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Chemokines are small chemotactic proteins that coordinate circulation of immune/inflammatory cells throughout body compartments. Because of this property chemokines and their cell surface receptors are implicated in several physiological and pathological conditions, including cancer. These molecules are expressed by neoplastic or stromal cells and have effects at tumor primary site (e.g. stimulating angiogenesis and tumor cells motility) and lymph nodes (creating a gradient to direct migration of neoplastic cells). In this article we review the current knowledge about the function(s) of chemokines and receptors in squamous cell carcinoma from the oral cavity and head and neck region. Accumulating evidence suggests some chemokine(s) and receptor(s) as potential targets in adjuvant therapies for these malignancies.
Abstract
Assunto
Chemokines, Inflammation, Squamous cell carcinoma of head and neck, Angiogenesis, Cell movement
Palavras-chave
Chemokines, Head and neck squamous cell carcinoma, Inflammation.
Citação
Curso
Endereço externo
https://www.sciencedirect.com/science/article/pii/S1368837516000464?via%3Dihub