Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: a critical review

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dc.creatorJanine Mayra da Silva
dc.creatorDanilo Figueiredo Soave
dc.creatorTálita Pollyanna Moreira dos Santos
dc.creatorAline Carvalho Batista
dc.creatorRemo Castro Russo
dc.creatorMauro Martins Teixeira
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2025-04-15T19:12:59Z
dc.date.accessioned2025-09-09T00:31:58Z
dc.date.available2025-04-15T19:12:59Z
dc.date.issued2016-05
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2016.02.016
dc.identifier.issn1879-0593
dc.identifier.urihttps://hdl.handle.net/1843/81625
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral oncology
dc.rightsAcesso Restrito
dc.subjectChemokines
dc.subjectInflammation
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectAngiogenesis
dc.subjectCell movement
dc.subject.otherChemokines
dc.subject.otherHead and neck squamous cell carcinoma
dc.subject.otherInflammation.
dc.titleSignificance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: a critical review
dc.typeArtigo de periódico
local.citation.epage16
local.citation.spage8
local.citation.volume56
local.description.resumoChemokines are small chemotactic proteins that coordinate circulation of immune/inflammatory cells throughout body compartments. Because of this property chemokines and their cell surface receptors are implicated in several physiological and pathological conditions, including cancer. These molecules are expressed by neoplastic or stromal cells and have effects at tumor primary site (e.g. stimulating angiogenesis and tumor cells motility) and lymph nodes (creating a gradient to direct migration of neoplastic cells). In this article we review the current knowledge about the function(s) of chemokines and receptors in squamous cell carcinoma from the oral cavity and head and neck region. Accumulating evidence suggests some chemokine(s) and receptor(s) as potential targets in adjuvant therapies for these malignancies.
local.identifier.orcidhttps://orcid.org/0000-0002-1473-7455
local.identifier.orcidhttps://orcid.org/0000-0001-9782-3940
local.identifier.orcidhttps://orcid.org/0000-0002-9299-6858
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.identifier.orcidhttps://orcid.org/0000-0002-1715-3834
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1368837516000464?via%3Dihub

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