DNA/RNA hybrid mesoscopic model shows strong stability dependence with deoxypyrimidine content and stacking interactions similar to RNA/RNA
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Despite the importance of DNA/RNA hybrids, a mesoscopic approach is still missing. We developed a mesoscopic
model for DNA/RNA hybrids and obtained the complete parametrization from published melting temperatures.
The new parameters show very clearly the reduced strength of the hydrogen bond of dArU base pairs, resulting
in a weakened stabilization of the double helix and a strong stability dependence on deoxypyrimidine content.
The stacking parameters show no correlation to B-DNA, however we obtain a moderate correlation to A-RNA.
We discuss some example sequences with variable deoxypyrimidine contents and for polipurine tracts (PPT).
Abstract
Assunto
Biofísica, Ácido desoxirribonucleico, DNA, Hidrogênio
Palavras-chave
DNA/RNA hybrid, Peyrard-Bishop DNA model, DNA/RNA stability, Hydrogen bonds, Stacking interaction
Citação
Departamento
Curso
Endereço externo
https://www.sciencedirect.com/science/article/pii/S0009261418309291?via%3Dihub