DNA/RNA hybrid mesoscopic model shows strong stability dependence with deoxypyrimidine content and stacking interactions similar to RNA/RNA

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dc.creatorErik de Oliveira Martins
dc.creatorVivianne Basílio Barbosa
dc.creatorGerald Weber
dc.date.accessioned2024-03-04T12:21:46Z
dc.date.accessioned2025-09-09T00:45:21Z
dc.date.available2024-03-04T12:21:46Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.cplett.2018.11.015
dc.identifier.issn0009-2614
dc.identifier.urihttps://hdl.handle.net/1843/65107
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemical Physics Letters
dc.rightsAcesso Restrito
dc.subjectBiofísica
dc.subjectÁcido desoxirribonucleico
dc.subjectDNA
dc.subjectHidrogênio
dc.subject.otherDNA/RNA hybrid
dc.subject.otherPeyrard-Bishop DNA model
dc.subject.otherDNA/RNA stability
dc.subject.otherHydrogen bonds
dc.subject.otherStacking interaction
dc.titleDNA/RNA hybrid mesoscopic model shows strong stability dependence with deoxypyrimidine content and stacking interactions similar to RNA/RNA
dc.typeArtigo de periódico
local.citation.epage19
local.citation.spage14
local.citation.volume715
local.description.resumoDespite the importance of DNA/RNA hybrids, a mesoscopic approach is still missing. We developed a mesoscopic model for DNA/RNA hybrids and obtained the complete parametrization from published melting temperatures. The new parameters show very clearly the reduced strength of the hydrogen bond of dArU base pairs, resulting in a weakened stabilization of the double helix and a strong stability dependence on deoxypyrimidine content. The stacking parameters show no correlation to B-DNA, however we obtain a moderate correlation to A-RNA. We discuss some example sequences with variable deoxypyrimidine contents and for polipurine tracts (PPT).
local.identifier.orcidhttps://orcid.org/0000-0002-4480-6298
local.identifier.orcidhttps://orcid.org/0000-0002-2935-1571
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0009261418309291?via%3Dihub

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