Evaluation of the cytotoxicity and biocompatibility of new resin epoxy-based endodontic sealer containing calcium hydroxide

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dc.creatorLuciano Tavares Angelo Cintra
dc.creatorFrancine Benetti
dc.creatorÍndia Olinta de Azevedo Queiroz
dc.creatorLuciana Louzada Ferreira
dc.creatorLoiane Massunari
dc.creatorCarlos Roberto Emerenciano Bueno
dc.creatorSandra Helena Penha de Oliveira
dc.creatorGomes-Filho
dc.date.accessioned2022-09-24T19:18:01Z
dc.date.accessioned2025-09-09T00:34:07Z
dc.date.available2022-09-24T19:18:01Z
dc.date.issued2017-12
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.joen.2017.07.016
dc.identifier.issn00992399
dc.identifier.urihttps://hdl.handle.net/1843/45466
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Endodontics
dc.rightsAcesso Restrito
dc.subjectMaterials testing
dc.subjectCalcium hydroxide
dc.subjectEpoxy resins
dc.subjectNoxae
dc.subject.otherBiocompatibility
dc.subject.otherCalcium hydroxide
dc.subject.otherCytotoxicity
dc.subject.otherEndodontic sealers
dc.subject.otherResin epoxy
dc.titleEvaluation of the cytotoxicity and biocompatibility of new resin epoxy-based endodontic sealer containing calcium hydroxide
dc.typeArtigo de periódico
local.citation.epage2092
local.citation.issue12
local.citation.spage2088
local.citation.volume43
local.description.resumoIntroduction: Many endodontic sealers are available, but the search for the ideal sealer continues. This study evaluated the cytotoxicity and biocompatibility of Sealer Plus, a new resin epoxy–based endodontic sealer con- taining calcium hydroxide. AH Plus, Endofill, and Simpli- Seal endodontics sealers were used for comparison. Methods: L929 fibroblasts were cultured, and an MTT assay was used to determine the cytotoxicity of the sealer extracts at 6, 24, 48, and 72 hours. Tubes contain- ing materials or empty tubes for control were inserted into the subcutaneous tissues of 20 rats. After 7 and 30 days, the rats were killed, and the tubes were removed with the surrounding tissues for histologic analysis. The data were submitted to statistical tests (P < .05). Results: Undiluted Sealer Plus exhibited less cytotoxicity compared with other undiluted extracts at 6 hours (P < .05), and cell viability was higher for all Sealer Plus extracts after 24 hours (P < .05). At 48 hours, the undiluted and ½ Sealer Plus dilution were the ex- tracts with less cytotoxicity (P < .05). At 72 hours, cell viability was higher for the undiluted and ½ Sealer Plus dilution compared with the other sealers (P < .05). At 7 days, Endofill and SimpliSeal had higher inflammation compared with the control and Sealer Plus (P < .05); AH Plus had moderate inflammation (P > .05). At 30 days, control, Sealer Plus, and AH Plus had less inflammation (P < .05). The fibrous capsule was thick at 7 days and thin at 30 days, except for SimpliSeal. Conclusions: In general, Sealer Plus promoted greater cell viability and was more biocompatible compared with the other sealers.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0099239917309056?via%3Dihub

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