Synthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier: enhanced cellular and nuclear uptake
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.
Abstract
Assunto
Fluorescência, Peptídios - Síntese, Triazóis, Transporte biológico
Palavras-chave
Fluorescence, Membranes, Peptides and proteins, Permeability, Triazole
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https://pubs.acs.org/doi/10.1021/acs.orglett.6b03776