Synthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier: enhanced cellular and nuclear uptake

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dc.creatorFlaviane Francisco Hilário
dc.creatorMohamed Dit Mady Traoré
dc.creatorVincent Zwick
dc.creatorLaurence Berry
dc.creatorCláudia Avello Simões Pires
dc.creatorMuriel Cuendet
dc.creatorNicolas Fantozzi
dc.creatorRossimiriam Pereira de Freitas
dc.creatorMarjorie Maynadier
dc.creatorSharon Wein
dc.creatorHenri Vial
dc.creatorYung-Sing Wong
dc.date.accessioned2024-08-01T13:30:42Z
dc.date.accessioned2025-09-09T01:20:37Z
dc.date.available2024-08-01T13:30:42Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1021/acs.orglett.6b03776
dc.identifier.issn1523-7052
dc.identifier.urihttps://hdl.handle.net/1843/72257
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOrganic Letters
dc.rightsAcesso Restrito
dc.subjectFluorescência
dc.subjectPeptídios - Síntese
dc.subjectTriazóis
dc.subjectTransporte biológico
dc.subject.otherFluorescence
dc.subject.otherMembranes
dc.subject.otherPeptides and proteins
dc.subject.otherPermeability
dc.subject.otherTriazole
dc.titleSynthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier: enhanced cellular and nuclear uptake
dc.typeArtigo de periódico
local.citation.epage615
local.citation.issue3
local.citation.spage612
local.citation.volume19
local.description.resumoA small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.
local.identifier.orcidhttps://orcid.org/0000-0001-6974-3724
local.identifier.orcidhttps://orcid.org/0000-0003-1038-9681
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://pubs.acs.org/doi/10.1021/acs.orglett.6b03776

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