Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones

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Artigo de periódico

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Resumo

We report a sequential C–H iodination/organoyl-thiolation of naphthoquinones and their relevant trypanocidal activity. Under a combination of AgSR with a copper source, sulfur-substituted benzenoid quinones were prepared in high yields (generally >90%). This provides an efficient and general method for preparing A-ring modified naphthoquinoidal systems, recognized as a challenge in quinone chemistry.

Abstract

Assunto

Química orgânica, Quinona

Palavras-chave

Quinone chemistry, Naphthoquinones, Trypanocidal quinones, Organoyl-thiolation, Iodination

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Endereço externo

https://pubs.rsc.org/en/content/articlelanding/2018/ob/c8ob00196k

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