Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones

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dc.creatorGuilherme Augusto de Melo Jardim
dc.creatorWillian Xerxes Coelho Oliveira
dc.creatorRossimiriam Pereira de Freitas
dc.creatorRubem Figueiredo Sadok Menna Barreto
dc.creatorThaissa Lúcio Silva
dc.creatorMarilia Oliveira Fonseca Goulart
dc.creatorEufrânio Nunes da Silva Júnior
dc.date.accessioned2024-02-08T18:16:46Z
dc.date.accessioned2025-09-09T00:45:18Z
dc.date.available2024-02-08T18:16:46Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1039/C8OB00196K
dc.identifier.issn1477-0539
dc.identifier.urihttps://hdl.handle.net/1843/63873
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOrganic & Biomolecular Chemistry
dc.rightsAcesso Restrito
dc.subjectQuímica orgânica
dc.subjectQuinona
dc.subject.otherQuinone chemistry
dc.subject.otherNaphthoquinones
dc.subject.otherTrypanocidal quinones
dc.subject.otherOrganoyl-thiolation
dc.subject.otherIodination
dc.titleDirect sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones
dc.typeArtigo de periódico
local.citation.epage1691
local.citation.issue10
local.citation.spage1686
local.citation.volume16
local.description.resumoWe report a sequential C–H iodination/organoyl-thiolation of naphthoquinones and their relevant trypanocidal activity. Under a combination of AgSR with a copper source, sulfur-substituted benzenoid quinones were prepared in high yields (generally >90%). This provides an efficient and general method for preparing A-ring modified naphthoquinoidal systems, recognized as a challenge in quinone chemistry.
local.identifier.orcidhttps://orcid.org/0000-0002-9882-3085
local.identifier.orcidhttps://orcid.org/0000-0003-0722-5352
local.identifier.orcidhttps://orcid.org/0000-0001-6974-3724
local.identifier.orcidhttps://orcid.org/0000-0002-1352-0641
local.identifier.orcidhttps://orcid.org/0000-0001-6557-8653
local.identifier.orcidhttps://orcid.org/0000-0001-9860-3667
local.identifier.orcidhttps://orcid.org/0000-0003-1281-5453
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://pubs.rsc.org/en/content/articlelanding/2018/ob/c8ob00196k

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