Medicamentos que influenciam na osseointegração: uma revisão a respeito de anti-inflamatórios, bisfosfonatos e estatinas

Abstract

The use of drugs can influence several metabolic aspects in the body and osseointegration could not be diferent. Of the drugs studied here, the nonsteroidal antiinflammatory drugs are of great concern in the literature. It is indisputable that prostaglandins have effects on bone homeostasis. But it is not known that the effects of inhibition of the synthesis of these non steroidal anti-inflammatories are sufficient for some concern during the installation of dental implants. The prolonged use of steroidal anti-inflammatory drugs and bisphosphonates can be worrisome. The first can cause numerous physiological changes, like the osteoporosis and inhibition of the hypothalamic-pituitary axis. Already the latter one hasbeen of concern by osseonecrosis of the jaws. However, like statins, the topical use of bisphosphonates has seemed promising. Statins commonly used in the treatment of hyperlipidemia, as bisphosphonates increase bone formation rate, by promoting the osteoblastic activityand inhibiting osteoclast activity. However, there are no reports of jaws osseonecrose associated with its use, unlike bisphosphonates.As we have seen, despite extensive discussions and controversies in theliterature, we can see that the use of the studied medications, can have both positive and negative influences on the success of implants or bone grafts