Papel dos receptores CCR1 na perda óssea alveolar em modelo de osteoporose

Abstract

The role of estrogen in bone metabolism/remodeling is well established in long bones, but its effect on alveolar bone is still unclear. The aim of the study was to determine the effect of estrogen deficiency on alveolar bone microarchitecture. C57BL6/J mice deficient in CCR1 receptors and C57BL6/J mice treated with met-RANTES were ovariectomized. Mice with intact ovaries were used as controls. As determined by MicroCT analysis and histomorphometric analysis of maxillary alveolar bone, both C57BL6/J mice showed decreased trabecular thickness, bone density, and bone volume, and increased trabecular separation after ovariectomy. These effects were associated with a reduction in the percentage of trabecular bone and cortical thickness in the femur. Significant loss of alveolar bone crest was also associated with ovariectomy in both strains of mice. In conclusion, CCR1 receptor deficiency and treatment with met-RANTES decrease bone quality, however, estrogen deficiency worsens all bone health parameters in these animals, generating maxillary alveolar bone loss.