Infection surveillance in pediatric hematopoietic stem cell transplantation recipients
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Objective: To describe the profile of reported healthcare- associated infections (HAIs) in pediatric patients submitted to hematopoietic stem cell transplantation (HSCT) at a reference center.Methods: Retrospective cohort of pediatric patients who were submitted to HSCT
from 2008 to 2016. The criteria for HAI were based on those established by the National Healthcare Safety Network. Data were collected by active surveillance per formed daily by professionals. This study was approved by the institutional research
ethics committee. Results: A total of 86 HSCTs were performed in 81 patients younger than 18 years of age (median, 10 years). Of these, 69 (85%) were males. Aplastic anemia and leukemia were the main diagnoses. A total of 140 HAIs were diagnosed with an incidence density of 28.2 infections/1000 patient- days. The most common HAI was laboratory confirmed bloodstream infection (46), the majority of which was reported to be central venous catheter- associated (43). Gram- negative bacteria were the most prevalent mi croorganisms (58.5%). Almost all the infections occurred until 30 days after transplan tation, and 17 deaths were observed within 180 days after the procedure. Conclusion: Active surveillance of HAIs in HSCT children allowed the evaluation of the incidence and profile of HAIs, which is essential for the health care of these patients.
Abstract
Assunto
Transplante de Medula Óssea, Hematologia, Transplante de Células-Tronco Hematopoéticas
Palavras-chave
bone marrow transplantation, Hematology, Immunology and infectious diseases, Hematopoietic stem cell transplantation
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https://onlinelibrary.wiley.com/doi/10.1111/ejh.12982