Loss of heterozygosity and cell proliferation in oral lichenoid lesions related to amalgam

Página do item simplificado
dc.creatorLeonardo Nogueira Rodrigues
dc.creatorCarolina Cavalieri Gomes
dc.creatorSílvia Ferreira de Sousa
dc.creatorRaíssa Cristina Costa Silva
dc.creatorRicardo Santiago Gomez
dc.creatorRicardo Alves de Mesquita
dc.creatorFábio Ramôa Pires
dc.creatorVanessa Fátima Bernardes
dc.date.accessioned2025-06-10T20:14:17Z
dc.date.accessioned2025-09-09T00:23:38Z
dc.date.available2025-06-10T20:14:17Z
dc.date.issued2017-08
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2017.05.421
dc.identifier.issn2212-4411
dc.identifier.sici2
dc.identifier.urihttps://hdl.handle.net/1843/82886
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Radiology
dc.rightsAcesso Restrito
dc.subjectEvaluation study
dc.subjectCell proliferation
dc.subjectGenes
dc.subjectLoss of heterozygosity
dc.subjectLichen planus, oral
dc.subjectWounds and injuries
dc.subjectDental amalgam
dc.subjectMouth mucosa
dc.subjectChromosomes, human, pair 9
dc.subjectChromosomes, human, pair 11
dc.subjectChromosomes, human, pair 17
dc.subjectKi-67 antigen
dc.subjectImmunohistochemistry
dc.titleLoss of heterozygosity and cell proliferation in oral lichenoid lesions related to amalgam
dc.typeArtigo de periódico
local.citation.epagee146
local.citation.issue2
local.citation.spagee146
local.citation.volume124
local.description.resumoOral lichenoid lesions related to amalgam (OLLRA) and oral lichen planus (OLP) share clinical and histopathologic features with molecular pathogenesis under clarification. Objective Here investigated loss of heterozygosity (LOH) in OLLRA, OLP and normal oral mucosa (NOM) using polymorphic microsatellite markers close to tumor suppressor genes and evaluated the index of cell proliferation in paraffin-embedded tissues. Study Design The sample comprised 10 OLLRAs, 10 OLPs and 8 NOMs matched by gender and age of the patient. LOH was assessed on 9p (D9S157, D9S162, D9S171), 11q (D11S1369) and 17p (TP53, AFM238WF2) chromosomes loci. The cell proliferation was assessed by immunohistochemical expression of Ki-67 (MIB-1). Results LOH was identified in 5 OLLRAs and in 2 OLPs in at least 1 marker while NOM showed no LOH. The index of Ki-67 expression in OLLRA was considered low (below 25%). There was no association between cell proliferation and LOH. Conclusions This study demonstrates that OLLRA and OLP have LOH in the 9p and 17p chromosomal regions and low expression of ki-67. Despite the lack of association between LOH and cell proliferation, it can be assumed that LOH occurs in OLLRA and it should be considered in the pathogenesis of this lesion.
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.identifier.orcidhttps://orcid.org/0000-0003-0317-8878
local.identifier.orcidhttps://orcid.org/0000-0003-0194-7434
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.oooojournal.net/article/S2212-4403(17)30720-4/fulltext

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Evento

Logo UFMG