Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Three novel cobalt(III)-triazole complexes with structural and redox properties suitable for hypoxia-activated drug delivery were obtained. A major influence of the ancillary ligands (TPA, py2en, py2 enMe2 ) on the electronic properties and reactivity of their complexes was observed. An [O2 ]-dependent reduction to cobalt(II) by ascorbic acid provided evidence of hypoxic selectivity.
Abstract
Assunto
Cobalto, Câncer, Anoxemia
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Cobalt, Cancer, Hypoxia
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https://pubs.rsc.org/en/content/articlelanding/2016/DT/C6DT02456D