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Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery

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dc.creatorIsabela Cristina Aguiar de Souza Borguignon
dc.creatorLetícia Villafranca Faro
dc.creatorDaniel Tadeu Gomes Gonzaga
dc.creatorCarlos Basílio Pinheiro
dc.creatorFernando de Carvalho da Silva
dc.creatorVitor Francisco Ferreira
dc.creatorFabio da Silva Miranda
dc.creatorMarciela Scarpellini
dc.creatorMauricio Lanznaster
dc.date.accessioned2023-07-17T14:58:53Z
dc.date.accessioned2025-09-09T00:21:05Z
dc.date.available2023-07-17T14:58:53Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.identifier.doihttps://doi.org/10.1039/c6dt02456d
dc.identifier.issn1477-9234
dc.identifier.urihttps://hdl.handle.net/1843/56382
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofDalton Transactions
dc.rightsAcesso Restrito
dc.subjectCobalto
dc.subjectCâncer
dc.subjectAnoxemia
dc.subject.otherCobalt
dc.subject.otherCancer
dc.subject.otherHypoxia
dc.titleInvestigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery
dc.typeArtigo de periódico
local.citation.epage13674
local.citation.issue35
local.citation.spage13671
local.citation.volume45
local.description.resumoThree novel cobalt(III)-triazole complexes with structural and redox properties suitable for hypoxia-activated drug delivery were obtained. A major influence of the ancillary ligands (TPA, py2en, py2 enMe2 ) on the electronic properties and reactivity of their complexes was observed. An [O2 ]-dependent reduction to cobalt(II) by ascorbic acid provided evidence of hypoxic selectivity.
local.identifier.orcidhttps://orcid.org/0000-0002-5755-5387
local.identifier.orcidhttps://orcid.org/0000-0001-6991-0166
local.identifier.orcidhttps://orcid.org/0000-0002-8674-1779
local.identifier.orcidhttps://orcid.org/0000-0002-2042-3778
local.identifier.orcidhttps://orcid.org/0000-0002-2166-766X
local.identifier.orcidhttps://orcid.org/0000-0001-9977-242X
local.identifier.orcidhttps://orcid.org/0000-0003-4784-5513
local.identifier.orcidhttps://orcid.org/0000-0003-0477-0152
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://pubs.rsc.org/en/content/articlelanding/2016/DT/C6DT02456D

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