Evaluation of strontium ranelate in the repair of standardized intrabuccal bone defects in a rat mode
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Abstract: The treatment of intrabuccal bone defects and the search for new agents to optimize regeneration proce
dures are extremely valuable. The present experimental study aimed to evaluate the effects of orally administered
Strontium Ranelate (SrR), in the repair of intrabuccal bone defects in rats. Twenty Lewis rats, divided in 4 groups
(2 control and 2 test groups) were used and evaluated at 14 and 42 days. Standardized bone defects in the distal
alveolar region of the orst superior molar were created in all animals. Test groups received a daily dose of SrR (625
mg/kg), and control groups received a placebo. Bone neoformation within the defects were evaluated through
histological and morphometric analysis. At 14 days, histological analysis revealed similar healing patterns between
groups. However, at 42 days, the test group presented healing patterns with better tissue organization, compatible
with slightly advanced bone maturation. At 14 days, morphometric analysis revealed a higher rate of bone deposi
tion in the test group when compared to the control group (P<0.05). At 42 days, no signiocant differences between
groups were observed in relation to morphometric parameters. SrR seemed to accelerate the process of bone
neoformation.
Abstract
Assunto
Bone Regeneration, Calcification, physiologic, Histology, Anthropometry, Wound healing, Evaluation study, Pharmaceutical preparations
Palavras-chave
Bone mineralization, Bone regeneration, Intrabuccal bone defects, Strontium ranelate
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https://e-century.us/web/journal_toc.php?journal=ijcem&volume=10&number=7