Evaluation of strontium ranelate in the repair of standardized intrabuccal bone defects in a rat mode

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dc.creatorSergio Antonucci Amaral
dc.creatorIgor Daniel Garcia Reis
dc.creatorPeterson Antônio Dutra Oliveira
dc.creatorFernando de Oliveira Costa
dc.creatorAlfredo Miranda de Goes
dc.creatorGerluza Aparecida Borges Silva
dc.creatorLuis Otávio de Miranda Cota
dc.date.accessioned2025-06-12T19:36:05Z
dc.date.accessioned2025-09-09T01:16:57Z
dc.date.available2025-06-12T19:36:05Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.issn1940-5901
dc.identifier.urihttps://hdl.handle.net/1843/82926
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.rightsAcesso Aberto
dc.subjectBone Regeneration
dc.subjectCalcification, physiologic
dc.subjectHistology
dc.subjectAnthropometry
dc.subjectWound healing
dc.subjectEvaluation study
dc.subjectPharmaceutical preparations
dc.subject.otherBone mineralization
dc.subject.otherBone regeneration
dc.subject.otherIntrabuccal bone defects
dc.subject.otherStrontium ranelate
dc.titleEvaluation of strontium ranelate in the repair of standardized intrabuccal bone defects in a rat mode
dc.typeArtigo de periódico
local.citation.epage10624
local.citation.issue7
local.citation.spage10616
local.citation.volume10
local.description.resumoAbstract: The treatment of intrabuccal bone defects and the search for new agents to optimize regeneration proce dures are extremely valuable. The present experimental study aimed to evaluate the effects of orally administered Strontium Ranelate (SrR), in the repair of intrabuccal bone defects in rats. Twenty Lewis rats, divided in 4 groups (2 control and 2 test groups) were used and evaluated at 14 and 42 days. Standardized bone defects in the distal alveolar region of the orst superior molar were created in all animals. Test groups received a daily dose of SrR (625 mg/kg), and control groups received a placebo. Bone neoformation within the defects were evaluated through histological and morphometric analysis. At 14 days, histological analysis revealed similar healing patterns between groups. However, at 42 days, the test group presented healing patterns with better tissue organization, compatible with slightly advanced bone maturation. At 14 days, morphometric analysis revealed a higher rate of bone deposi tion in the test group when compared to the control group (P<0.05). At 42 days, no signiocant differences between groups were observed in relation to morphometric parameters. SrR seemed to accelerate the process of bone neoformation.
local.identifier.orcidhttps://orcid.org/0000-0002-6299-0658
local.identifier.orcidhttps://orcid.org/0000-0002-7687-1238
local.identifier.orcidhttps://orcid.org/0000-0002-0262-949X
local.identifier.orcidhttps://orcid.org/0000-0003-1517-5842
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://e-century.us/web/journal_toc.php?journal=ijcem&volume=10&number=7

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