A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet

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dc.creatorMaria Luíza R. P. Lima
dc.creatorLaura H. R. Leite
dc.creatorCarolina R. Gioda
dc.creatorFabiola de Oliveira Paes Leme
dc.creatorClaudia A. Couto
dc.creatorCândido C. Coimbra
dc.creatorVirginia H. R. Leite
dc.creatorTeresa Cristina A. Ferrari
dc.date.accessioned2024-04-12T20:15:00Z
dc.date.accessioned2025-09-09T00:57:28Z
dc.date.available2024-04-12T20:15:00Z
dc.date.issued2016
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1155/2016/9127076
dc.identifier.issn2314-6753
dc.identifier.urihttps://hdl.handle.net/1843/67137
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Diabetes Research
dc.rightsAcesso Aberto
dc.subjectRatos Wistar
dc.subjectHepatopatia gordurosa não alcoólica
dc.subjectSacarose na dieta
dc.subjectObesidade
dc.subject.otherWistar Rat
dc.subject.otherNonalcoholic fatty liver disease
dc.subject.otherSucrose-rich diet
dc.subject.otherObesity
dc.titleA novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
dc.typeArtigo de periódico
local.citation.volume2016
local.description.resumoThe pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood, and experimental models are an alternative to study this issue. We investigated the effects of a simple carbohydrate-rich diet on the development of obesity-related NAFLD and the impact of physical training on the metabolic abnormalities associated with this disorder. Sixty Wistar rats were randomly separated into experimental and control groups, which were fed with sucrose-enriched (18% simple carbohydrates) and standard diet, respectively. At the end of each experimental period (5, 10, 20, and 30 weeks), 6 animals from each group were sacrificed for blood tests and liver histology and immunohistochemistry. From weeks 25 to 30, 6 animals from each group underwent physical training. The experimental group animals developed obesity and NAFLD, characterized histopathologically by steatosis and hepatocellular ballooning, clinically by increased thoracic circumference and body mass index associated with hyperleptinemia, and metabolically by hyperglycemia, hyperinsulinemia, hypertriglyceridemia, increased levels of very low-density lipoprotein- (VLDL-) cholesterol, depletion of the antioxidants liver enzymes superoxide dismutase and catalase, and increased hepatic levels of malondialdehyde, an oxidative stress marker. Rats that underwent physical training showed increased high-density lipoprotein- (HDL-) cholesterol levels. In conclusion, a sucrose-rich diet induced obesity, insulin resistance, oxidative stress, and NAFLD in rats.
local.identifier.orcidhttps://orcid.org/0000-0002-4013-0147
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.hindawi.com/journals/jdr/2016/9127076/

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