Overexpression of immunomodulatory mediators in oral precancerous lesions
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Human leukocyte antigen (HLA) G and E, programmed cell death 1 ligand 1 (PD-L1), IL-10 and TGF-β are proteins involved in failure of the antitumor immune response. We investigated the expression of these immunomodulatory mediators in oral precancerous lesions (oral leukoplakia-OL; n=80) and whether these molecules were related to the risk of malignant transformation. Samples of normal mucosa (n=20) and oral squamous cells carcinoma (OSCC, n=20) were included as controls. Tissue and saliva samples were analyzed by immunohistochemistry and ELISA respectively. Fifteen OL samples showed severe dysplasia (18.7%) and 40 samples (50%) presented combined high Ki-67/p53. Irrespective of the degree of epithelial dysplasia and the proliferation/apoptosis index of OL, the expression of HLA-G, -E, PD-L1, IL-10, TGF-β2 and -β3 was higher to control (P<0.05) and similar to OSCC (P>0.05). The number of granzyme B+ cells in OL was similar to control (P=0.28) and lower compared to OSCC (P<0.01). Salivary concentrations of sHLA-G, IL-10 and TGF-β did not allow for a distinction between OL and healthy individuals. Overexpression of immunosuppressive mediators in the OL reflects the immune evasion potential of this lesion, which is apparently independent of at cytological and proliferation/apoptosis status.
Abstract
Assunto
HLA-G antigens, Immune evasion, B7-H1 antigen, Mouth neoplasms, Ki-67 antigen, Cytokines, HLA-E antigens, Saliva, Immunosuppressive agents
Palavras-chave
HLA-G, Immune evasion, Oral cancer, Oral leucoplakia, Programmed cell death 1 ligand 1
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https://www.sciencedirect.com/science/article/pii/S0198885917304949?via%3Dihub