Overexpression of immunomodulatory mediators in oral precancerous lesions

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dc.creatorAndréia Souza Gonçalves
dc.creatorCarla Mosconi
dc.creatorFilipe Jaeger
dc.creatorIsabela Jubé Wastowski
dc.creatorMaria Cássia Ferreira de Aguiar
dc.creatorTarcília Aparecida da Silva
dc.creatorRejane Faria Ribeiro-Rotta
dc.creatorNádia Lago Costa
dc.creatorAline Carvalho Batista
dc.date.accessioned2025-04-03T19:26:43Z
dc.date.accessioned2025-09-09T00:28:54Z
dc.date.available2025-04-03T19:26:43Z
dc.date.issued2017-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.humimm.2017.09.003
dc.identifier.issn1879-1166
dc.identifier.urihttps://hdl.handle.net/1843/81282
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHuman Immunology
dc.rightsAcesso Restrito
dc.subjectHLA-G antigens
dc.subjectImmune evasion
dc.subjectB7-H1 antigen
dc.subjectMouth neoplasms
dc.subjectKi-67 antigen
dc.subjectCytokines
dc.subjectHLA-E antigens
dc.subjectSaliva
dc.subjectImmunosuppressive agents
dc.subject.otherHLA-G
dc.subject.otherImmune evasion
dc.subject.otherOral cancer
dc.subject.otherOral leucoplakia
dc.subject.otherProgrammed cell death 1 ligand 1
dc.titleOverexpression of immunomodulatory mediators in oral precancerous lesions
dc.typeArtigo de periódico
local.citation.epage757
local.citation.issue11-12
local.citation.spage752
local.citation.volume78
local.description.resumoHuman leukocyte antigen (HLA) G and E, programmed cell death 1 ligand 1 (PD-L1), IL-10 and TGF-β are proteins involved in failure of the antitumor immune response. We investigated the expression of these immunomodulatory mediators in oral precancerous lesions (oral leukoplakia-OL; n=80) and whether these molecules were related to the risk of malignant transformation. Samples of normal mucosa (n=20) and oral squamous cells carcinoma (OSCC, n=20) were included as controls. Tissue and saliva samples were analyzed by immunohistochemistry and ELISA respectively. Fifteen OL samples showed severe dysplasia (18.7%) and 40 samples (50%) presented combined high Ki-67/p53. Irrespective of the degree of epithelial dysplasia and the proliferation/apoptosis index of OL, the expression of HLA-G, -E, PD-L1, IL-10, TGF-β2 and -β3 was higher to control (P<0.05) and similar to OSCC (P>0.05). The number of granzyme B+ cells in OL was similar to control (P=0.28) and lower compared to OSCC (P<0.01). Salivary concentrations of sHLA-G, IL-10 and TGF-β did not allow for a distinction between OL and healthy individuals. Overexpression of immunosuppressive mediators in the OL reflects the immune evasion potential of this lesion, which is apparently independent of at cytological and proliferation/apoptosis status.
local.identifier.orcidhttps://orcid.org/0000-0003-1787-3521
local.identifier.orcidhttps://orcid.org/0000-0002-8950-4605
local.identifier.orcidhttps://orcid.org/0000-0003-2893-4457
local.identifier.orcidhttps://orcid.org/0000-0001-5441-4186
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-3267-5745
local.identifier.orcidhttps://orcid.org/0000-0002-3298-867X
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0198885917304949?via%3Dihub

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