Hydroxyapatite nanoparticles: preparation, characterization, and evaluation of their potential use in bone targeting: an animal study

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dc.creatorAna Luiza Chaves Maia
dc.creatorCarolina Henriques Cavalcante
dc.creatorMarina Guedes Fonseca de Souza
dc.creatorCarolina de Aguiar Ferreira
dc.creatorDomenico Rubello
dc.creatorSotirios Chondrogiannis
dc.creatorValbert Nascimento Cardoso
dc.creatorGilson Andrade Ramaldes
dc.creatorAndré Luis Branco de Barros
dc.creatorDaniel Crístian Ferreira Soares
dc.date.accessioned2022-05-30T20:03:39Z
dc.date.accessioned2025-09-09T01:31:30Z
dc.date.available2022-05-30T20:03:39Z
dc.date.issued2016-07
dc.identifier.doi10.1097/MNM.0000000000000510
dc.identifier.issn0143-3636
dc.identifier.urihttps://hdl.handle.net/1843/42085
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNuclear Medicine Communications
dc.rightsAcesso Restrito
dc.subjectHidroxiapatita
dc.subjectDirecionamento ósseo
dc.subjectAnimais
dc.subjectNanopartículas radiomarcadas
dc.subject.otherRadiolabeled nanoparticles
dc.subject.otherMesoporous hydroxyapatite nanoparticles
dc.subject.otherControlled delivery system
dc.subject.otherBone targeting
dc.titleHydroxyapatite nanoparticles: preparation, characterization, and evaluation of their potential use in bone targeting: an animal study
dc.typeArtigo de periódico
local.citation.epage782
local.citation.issue7
local.citation.spage775
local.citation.volume37
local.description.resumoObjective Hydroxyapatite is used as a drug-delivery system for bone therapy applications because of its biocompatibility, bioactivity, and osteoconductive properties. In addition, hydroxyapatite nanoparticles (HApN) might be used as a theranostic probe. The aim of this study was to prepare and characterize hydroxyapatite mesoporous nanoparticles, and radiolabel these nanoparticles with technetium-99m (99mTc). Moreover, biodistribution studies were carried out in healthy mice. Materials and methods HApN were synthesized and characterized. 99mTc-HApN was prepared by adding 99mTc-pertechnetate to a dispersion of HApN in the presence of stannous chloride. Radiochemical purity and in-vitro stability were determined. The circulation time of 99mTc-HApN was determined by measuring blood radioactivity in healthy mice. In addition, biodistribution studies were carried out in healthy mice at 1 and 4 h after injection. Results 99mTc-HApN showed high radiochemical purity (98.7±0.2%) and in-vitro stability until 24 h. 99mTc-HApN levels in blood decreased in a biphasic manner, with an α half-life of 1.8 min and a β half-life of 126.9 min. High uptake was achieved in the liver and spleen because of the macrophage uptake. Furthermore, bone uptake was higher than that of the surrounding muscle, resulting in high bone-to-muscle ratios. Conclusion HApN were synthesized successfully with suitable characteristics for in-vivo applications. 99mTc-HApN was prepared and showed high stability. 99mTc-HApN presented increasing bone uptake over time, showing a higher affinity to bone tissues in contrast to surrounding muscle. The present results, together with further studies, may indicate a potential application of HApN as a nanocarrier for bone diseases.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/nuclearmedicinecomm/Abstract/2016/07000/Hydroxyapatite_nanoparticles__preparation,.12.aspx

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