The effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
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Introduction: The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.Objective: We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on
inflammatory markers in patients with diabetes as well as non-diabetic subjects.Methods: A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was con ducted through September 2017. Search terms included: “hypoglycemia”,“ insulin”, “cytokines”, and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.Results: Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers.Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypogly cemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers. Conclusion: Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic
nervous system is a likely mediator of these effects.
Abstract
Assunto
Hipoglicemia, Insulisina
Palavras-chave
Hypoglycemia, Insulin
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https://www.sciencedirect.com/science/article/pii/S0889159118301740?via%3Dihub