The effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review

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dc.creatorJuliana B.drummond
dc.creatorIzabela Guimarães Barbosa
dc.creatorRobert Dantzer
dc.creatorAntonio l. Teixeira
dc.date.accessioned2023-07-17T20:38:40Z
dc.date.accessioned2025-09-08T23:35:26Z
dc.date.available2023-07-17T20:38:40Z
dc.date.issued2018-05-04
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.bbi.2018.05.003
dc.identifier.issn08891591
dc.identifier.urihttps://hdl.handle.net/1843/56514
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrain, Behavior, and Immunity
dc.rightsAcesso Aberto
dc.subjectHipoglicemia
dc.subjectInsulisina
dc.subject.otherHypoglycemia
dc.subject.otherInsulin
dc.titleThe effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review
dc.typeArtigo de periódico
local.citation.epage50
local.citation.issue2018
local.citation.spage41
local.citation.volume73
local.description.resumoIntroduction: The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.Objective: We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.Methods: A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was con ducted through September 2017. Search terms included: “hypoglycemia”,“ insulin”, “cytokines”, and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.Results: Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers.Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypogly cemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers. Conclusion: Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0889159118301740?via%3Dihub

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