Pulp response of rats submitted to bleaching and the use of different anti-inflammatory drugs

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dc.creatorMarjorie de Oliveira Gallinari
dc.creatorLuciano Tavares Ângelo Cintra
dc.creatorFrancine Benetti
dc.creatorVanessa Rahal
dc.creatorEdilson Ervolino
dc.creatorAndré Luiz Fraga Briso
dc.date.accessioned2022-09-27T21:53:03Z
dc.date.accessioned2025-09-08T23:51:03Z
dc.date.available2022-09-27T21:53:03Z
dc.date.issued2019-01-08
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0210338
dc.identifier.issn19326203
dc.identifier.urihttps://hdl.handle.net/1843/45641
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPlos One
dc.rightsAcesso Aberto
dc.subjectTooth bleaching
dc.subjectImmunohistochemistry
dc.subjectHidrocortisona
dc.subjectAcetaminofén
dc.subjectInflammation
dc.titlePulp response of rats submitted to bleaching and the use of different anti-inflammatory drugs
dc.typeArtigo de periódico
local.citation.epage14
local.citation.issue1
local.citation.spage1
local.citation.volume14
local.description.resumoThis study aimed to evaluate neuropeptide expression after bleaching treatment using histo pathological and immunohistochemical analyses and the effects of hydrocortisone and acet aminophen on pulp inflammation, sine dental bleaching and inflammation first occur, and only then, the treatmentt. Sixty-three rats were divided into three groups (n = 21) according to the pain-relieving therapy used: I-control; II-topical application of Otosporin for 10 min after the bleaching treatment; III-oral administration of paracetamol 30 min before whitening and then every 12h. In all the study groups, placebo gel was applied to the left upper jaw (control) and a 35% H2O2-based whitening gel was applied to the right upper jaw for 45 min. Seven animals from each group were euthanized at different time points: 0h after treatment, 24h, and 48h. After euthanasia, the first molar on each side was analyzed by histology and immunohistochemistry to assess the degree of inflammation and verify the presence of the neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP). The data were analyzed using the statistical nonparametric Kruskal-Wallis test followed by Dunn’s test for individual comparisons. Extensive areas of necrosis were observed in the groups that received bleaching treatment only, whereas reduced damage were obtained in the group treated with Otosporin. The immunohistochemical analysis showed positive immuno labeling in all groups, including the control, but this was stronger in the groups that received bleaching treatment. The best results were obtained in the group that received treatment with Otosporin. The use of Otosporin after dental bleaching minimized the side effects of this treatment.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210338

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