Papéis de vias de sinalização intracelulares na doença de Alzheimer

Abstract

Neurodegenerative diseases are characterized by a progressive loss ofneurons, which results in damage to the motor control, cognitive, memory, among others. Alzheimer's disease (AD) is characterized by aneurodegenerative disorder in which there is the formation of senile plaques composed of amyloid beta protein. The senile plaques, as well as soluble oligomers cause neuronal death, which generates cognition deficits. This work, which is the result of a literature search in national and international journals indexed to Medline, Pubmed and Scielo between the years 1990 and 2015, which were found 115 articles, of which 68 were used and excluded 47, sought evidence in the literature about the possible role of intracellular signaling pathways in AD. The research was conducted using a paradigm between AD and its relationship with each of the most relevant signaling pathways of thisdisease. From this research it can be observed that different intracellularmolecules represent potential pharmacological tools for the delay of progression or for improvement in cognitive control of AD.