Estudo bibliométrico e análise in vivo da biocompatibilidade e bioatividade de cimentos biocerâmicos na endodontia

Abstract

Mineral Trioxide Aggregate (MTA) has a bioactive and biocompatible nature, having the ability to interact with the recipient tissue, stimulating its repair and regeneration; it is the material considered the reference standard for conservative pulp treatments and for scientific evaluations. This material is considered the gold standard for scientific research. Bibliometric analysis is a scientific method that allows for mapping and providing a historical perspective on scientific developments, as well as revealing research trends and the interconnections between researchers and study groups. New bioceramic materials, such as Biodentine and CIMMO DTA, have been used in clinical practice, as bioactive dentin substitutes. The objective of this study was to identify the main studies on bioceramic cements in endodontics and evaluate the biocompatibility and bioactivity of Biodentine and CIMMO DTA cements compared to white MTA (Angelus). A broad search strategy using the main terms related to bioceramic cements in endodontics was conducted in the Web of Science Core Collection (WoS-CC). Data were retrieved and organized in descending order of the number of WoS-CC references, and each article was compared with the number of references in Scopus and Google Scholar. Co-authorship networks were constructed using the VOSviewer software. Spearman's correlations were performed using the Statistical Package for Social Sciences (SPSS) software. Balb/c mice were used for cell collection and biocompatibility and bioactivity analysis. Cells were analyzed using the hematoxylin and eosin technique; and bioactivity was analyzed using polarized light analysis and the von Kossa technique. Data analyses were performed using the SPSS statistical program.