Cisto odontogênico calcificante: um estudo multicêntrico

Abstract

This study investigated the frequency of calcifying odontogenic cyst (COC) submitted to histopathological analysis in different geographic regions of Brazil. In a retrospective analysis (1953-2016), biopsy files of 10 Oral and Maxillofacial Pathology centers located in different states of Brazil: Goiás, Minas Gerais, Pará, Rio de Janeiro, Rio Grande do Norte, Rio Grande do Sul, Santa Catarina and São Paulo were analyzed. Demographic data, clinicopathological characteristics, radiographic aspects and treatment were evaluated descriptively. The Mann-Whitney test was used to determine the association between symptoms, evolution time and lesion size. Statistical significance was set as p<0.05. The diagnosis of COC was according to the classification of the World Health Organization (2017). In addition, a literature review of case series was carried out in four electronic databases (PubMed, Medline Ovid, Web of Science and Scopus). Of 198,350 specimens of biopsies analyzed, 268 cases of COC were surveyed, representing 0.1% of the oral lesions at the centers studied. Overall, female patients (n=142, 54.0%) in their second decade of life (n=76, 31.0%) and the maxilla (n=141, 54.4%) were more affected. The mean lesion size of symptomatic individuals was larger than that of cases without symptoms (p=0.026). The literature review showed a higher frequency in Asia (186 cases) and Europe (68 cases), mainly affecting men (n=247, 56.2%) in the third decade of life. COC is a rare lesion. Additional data on the clinicopathological features of 268 cases have been added to the literature. Data regarding gender and age of the Brazilian patients reported herein are different with findings of case series and retrospective studies reported in the literature. This study provides information that could help clinicians, pathologists, and surgeons in the diagnosis and management of COC.