Cytokine signatures associated with early onset, active lesions and late cicatricial events of retinochoroidal commitment in infants with congenital toxoplasmosis
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
Background. Ocular toxoplasmosis is a prominent and severe condition of high incidence in Brazil. The current study provides
new insights into the immunological events that can be associated with retinochoroiditis in the setting of congenital toxoplasmosis in
human infants. Methods. Flow cytometry of intracytoplasmic cytokines in leukocyte subsets following in vitro short-term antigenic recall in infants with congenital T. gondii infection. Results. Our data demonstrates that whereas neutrophils and monocytes from T. gondii–infected infants display a combination of proinflammatory and regulatory cytokine profiles, natural killer cells showed a predominantly proinflammatory profile upon in vitro T. gondii stimulation. The proinflammatory response of CD4+ and CD8+ T cells, characterized by the production of interferon γ (IFN-γ) and interleukin 17 in patients with an active retinochoroidal lesion, revealed the presence of IFN-γ and tumor necrosis factor α during early and late immunological events. This specific proinflammatory pattern is associated with early events and active retinochoroidal lesion, whereas a robust monocyte-derived interleukin 10–mediated profile is observed in children with cicatricial ocular lesions. Conclusions. These findings support the existence of a progressive immunological environment concomitant with the initial,apical, and cicatricial phases in the process of retinochoroidal lesion formation in infants with congenital toxoplasmosis that may be relevant in the establishment of stage-specific clinical management.
Abstract
Assunto
Toxoplasmose Congênita, Crianças, Coriorretinopatia de Birdshot
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Congenital toxoplasmosis, Cytokine profile, Retinochoroiditis, Infants, Active and cicatricial lesions
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https://academic.oup.com/jid/article/213/12/1962/2572144