Cytokine signatures associated with early onset, active lesions and late cicatricial events of retinochoroidal commitment in infants with congenital toxoplasmosis

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dc.creatorAna Carolina Aguiar Vasconcelos Carneiro
dc.creatorRicardo Wagner Almeida Vitor
dc.creatorOlindo Assis Martins-filho
dc.creatorUfmg Congenital Toxoplasmosis Group Brazilian 'ufmg-ctbg
dc.creatorJúlia Gatti Ladeia Costa
dc.creatorAnderson da Silva Machado
dc.creatorGláucia Manzan Queiroz Andrade
dc.creatorSamantha Ribeiro Béla
dc.creatorJordana g. Coelho-dos-reis
dc.creatorEloísa A.v. Ferro
dc.creatorJosé Nélio Januário
dc.creatorAndréa Teixeira-carvalho
dc.creatorDaniel Vitor Vasconcelos-santos
dc.date.accessioned2023-06-23T20:19:51Z
dc.date.accessioned2025-09-09T00:34:09Z
dc.date.available2023-06-23T20:19:51Z
dc.date.issued2016-03-05
dc.format.mimetypepdf
dc.identifier.doihttps://10.1093/infdis/jiw041
dc.identifier.issn00221899
dc.identifier.urihttps://hdl.handle.net/1843/55291
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Journal of Infectious Diseases
dc.rightsAcesso Aberto
dc.subjectToxoplasmose Congênita
dc.subjectCrianças
dc.subjectCoriorretinopatia de Birdshot
dc.subject.otherCongenital toxoplasmosis
dc.subject.otherCytokine profile
dc.subject.otherRetinochoroiditis
dc.subject.otherInfants
dc.subject.otherActive and cicatricial lesions
dc.titleCytokine signatures associated with early onset, active lesions and late cicatricial events of retinochoroidal commitment in infants with congenital toxoplasmosis
dc.typeArtigo de periódico
local.citation.epage1970
local.citation.issue12
local.citation.spage1962
local.citation.volume213
local.description.resumoBackground. Ocular toxoplasmosis is a prominent and severe condition of high incidence in Brazil. The current study provides new insights into the immunological events that can be associated with retinochoroiditis in the setting of congenital toxoplasmosis in human infants. Methods. Flow cytometry of intracytoplasmic cytokines in leukocyte subsets following in vitro short-term antigenic recall in infants with congenital T. gondii infection. Results. Our data demonstrates that whereas neutrophils and monocytes from T. gondii–infected infants display a combination of proinflammatory and regulatory cytokine profiles, natural killer cells showed a predominantly proinflammatory profile upon in vitro T. gondii stimulation. The proinflammatory response of CD4+ and CD8+ T cells, characterized by the production of interferon γ (IFN-γ) and interleukin 17 in patients with an active retinochoroidal lesion, revealed the presence of IFN-γ and tumor necrosis factor α during early and late immunological events. This specific proinflammatory pattern is associated with early events and active retinochoroidal lesion, whereas a robust monocyte-derived interleukin 10–mediated profile is observed in children with cicatricial ocular lesions. Conclusions. These findings support the existence of a progressive immunological environment concomitant with the initial,apical, and cicatricial phases in the process of retinochoroidal lesion formation in infants with congenital toxoplasmosis that may be relevant in the establishment of stage-specific clinical management.
local.identifier.orcidhttps://orcid.org/0000-0002-0912-3782
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PARASITOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/jid/article/213/12/1962/2572144

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