Kinetics of lumefantrine thermal decomposition employing isoconversional models and artificial neural network

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dc.creatorMaria Betânia de Freitas Marques
dc.creatorBárbara Caroline Rodrigues de Araújo
dc.creatorChristian Fernandes
dc.creatorMaria Irene Yoshida
dc.creatorWagner da Nova Mussel
dc.creatorRita de Cássia de Oliveira Sebastião
dc.date.accessioned2022-04-04T21:52:07Z
dc.date.accessioned2025-09-08T23:36:54Z
dc.date.available2022-04-04T21:52:07Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.21577/0103-5053.20190211
dc.identifier.issn0103-5053
dc.identifier.urihttps://hdl.handle.net/1843/40752
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso Aberto
dc.subjectLumefantrina
dc.subjectAntimalárico
dc.subjectCinética da decomposição térmica
dc.subject.otherSolid thermal stability
dc.subject.otherAntimalarial drug
dc.subject.otherKinetic triplet
dc.subject.otherThermogravimetry
dc.subject.otherMultilayer perceptron network
dc.titleKinetics of lumefantrine thermal decomposition employing isoconversional models and artificial neural network
dc.typeArtigo de periódico
local.citation.epage522
local.citation.issue3
local.citation.spage512
local.citation.volume31
local.description.resumoThermal analysis can be used to determine shelf-life and kinetic parameters in pharmaceutical systems. This work investigates the kinetic of lumefantrine thermal decomposition, an antimalarial, using non-isothermal and isothermal experimental data. The non-isothermal conditions are analyzed applying Vyazovkin method, while isothermal conditions employ models fitting procedure and artificial neural network. Lumefantrine was characterized by powder X-ray diffraction and Fourier transform infrared spectroscopy. The initial stage of lumefantrine thermal decomposition, about 5% of conversion, corresponds to the loss of chlorine and hydroxyl, being correctly predicted by the neural network as a complex event. At room temperature, the D3 model is appropriate to describe the process, once the half-life time is 19 months, in agreement with manufacturer. Isoconversional model determined the activation energy along the whole process while isothermal methodology determined the global value considering the entire process. The results provide important information for the pharmaceutical industry to assay levels of acceptable lumefantrine contents.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jbchs/a/bBmxxMZzr8zNQyfLHbJVM5F/?lang=en

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