Thermosensitive gemcitabine-magnetoliposomes for combined hyperthermia and chemotherapy
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Resumo
The combination of magnetic hyperthermia therapy with the controlled release of
chemotherapeutic agents in tumors may be an efficient therapeutic with few side effects because
the bioavailability, tolerance and amount of the drug can be optimized. Here, we prepared
magnetoliposomes consisting of magnetite nanoparticle cores and the anticancer drug
gemcitabine encapsulated by a phospholipid bilayer. The potential of these magnetoliposomes
for controlled drug release and cancer treatment via hyperthermic behavior was investigated. The
magnetic nanoparticle encapsulation efficiency was dependent on the initial amount of magnetite
nanoparticles present at the encapsulation stage; the best formulation was 66%. We chose this
formulation to characterize the physicochemical properties of the magnetoliposomes and to
encapsulate gemcitabine. The mean particle size and distribution were determined by dynamic
light scattering (DLS), and the zeta potential was measured. The magnetoliposome formulations
all had acceptable characteristics for systemic administration, with a mean size of approximately
150 nm and a polydispersity index <0.2. The magnetoliposomes were stable in aqueous
suspension for at least one week, as determined by DLS. Temperature increases due to the
dissipation energy of magnetoliposome suspensions subjected to an applied alternating magnetic
field (AMF) were measured at different magnetic field intensities, and the values were
appropriated for cancer treatments. The drug release profile at 37 °C showed that 17% of the
gemcitabine was released after 72 h. Drug release from magnetoliposomes exposed to an AMF
for 5 min reached 70%.
Abstract
Assunto
Hipertermia, Câncer, Nanopartículas, Quimioterapia
Palavras-chave
Brazilian MRS, Magnetite nanoparticles, Magnetoliposome, Magnetic hyperthermia, Drug release, Chemotherapy
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Endereço externo
https://iopscience.iop.org/article/10.1088/0957-4484/27/8/085105