Thermosensitive gemcitabine-magnetoliposomes for combined hyperthermia and chemotherapy

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dc.creatorRoberta Viana Ferreira
dc.creatorThaís Maria da Mata Martins
dc.creatorAlfredo Miranda de Goes
dc.creatorJosé Domingos Fabris
dc.creatorLuis Carlos Duarte Cavalcante
dc.creatorLuis Eugenio Fernandez Outon
dc.creatorRosana Zacarias Domingues
dc.date.accessioned2025-02-17T12:26:36Z
dc.date.accessioned2025-09-08T23:33:42Z
dc.date.available2025-02-17T12:26:36Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1088/0957-4484/27/8/085105
dc.identifier.issn1361-6528
dc.identifier.urihttps://hdl.handle.net/1843/80113
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNanotechnology
dc.rightsAcesso Restrito
dc.subjectHipertermia
dc.subjectCâncer
dc.subjectNanopartículas
dc.subjectQuimioterapia
dc.subject.otherBrazilian MRS
dc.subject.otherMagnetite nanoparticles
dc.subject.otherMagnetoliposome
dc.subject.otherMagnetic hyperthermia
dc.subject.otherDrug release
dc.subject.otherChemotherapy
dc.titleThermosensitive gemcitabine-magnetoliposomes for combined hyperthermia and chemotherapy
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue8
local.citation.spage1
local.citation.volume27
local.description.resumoThe combination of magnetic hyperthermia therapy with the controlled release of chemotherapeutic agents in tumors may be an efficient therapeutic with few side effects because the bioavailability, tolerance and amount of the drug can be optimized. Here, we prepared magnetoliposomes consisting of magnetite nanoparticle cores and the anticancer drug gemcitabine encapsulated by a phospholipid bilayer. The potential of these magnetoliposomes for controlled drug release and cancer treatment via hyperthermic behavior was investigated. The magnetic nanoparticle encapsulation efficiency was dependent on the initial amount of magnetite nanoparticles present at the encapsulation stage; the best formulation was 66%. We chose this formulation to characterize the physicochemical properties of the magnetoliposomes and to encapsulate gemcitabine. The mean particle size and distribution were determined by dynamic light scattering (DLS), and the zeta potential was measured. The magnetoliposome formulations all had acceptable characteristics for systemic administration, with a mean size of approximately 150 nm and a polydispersity index <0.2. The magnetoliposomes were stable in aqueous suspension for at least one week, as determined by DLS. Temperature increases due to the dissipation energy of magnetoliposome suspensions subjected to an applied alternating magnetic field (AMF) were measured at different magnetic field intensities, and the values were appropriated for cancer treatments. The drug release profile at 37 °C showed that 17% of the gemcitabine was released after 72 h. Drug release from magnetoliposomes exposed to an AMF for 5 min reached 70%.
local.identifier.orcidhttps://orcid.org/0000-0002-8934-2909
local.identifier.orcidhttps://orcid.org/0000-0002-0279-8314
local.identifier.orcidhttps://orcid.org/0000-0002-0262-949X
local.identifier.orcidhttps://orcid.org/0000-0002-2427-5995
local.identifier.orcidhttps://orcid.org/0000-0003-0477-9771
local.identifier.orcidhttps://orcid.org/0000-0003-3264-337X
local.identifier.orcidhttps://orcid.org/0000-0001-5667-2031
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://iopscience.iop.org/article/10.1088/0957-4484/27/8/085105

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