Immunohistochemical coexpression of epithelial cell adhesion molecule and alpha-fetoprotein in hepatocellular carcinoma
Carregando...
Data
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Minas Gerais
Descrição
Tipo
Artigo de periódico
Título alternativo
Primeiro orientador
Membros da banca
Resumo
Background and Aim. The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells
in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to
investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association
with clinicopathological characteristics. Methods. This study included Child-Pugh A HCC patients undergoing curative surgical
resection. Results. A significant difference was observed in the ratio between the different phenotypes (p = 0.002), identifying 12
(29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors. EpCAM+ expression was associated with AFP + (OR = 12.5, 95%
CI, 1.9-84.1, p<0.001). In univariate analysis, a significant association was observed between AFP+ and EPCAM+ and the serum
AFP level. A diameter of ≤ 5 cm was associated with EPCAM+, while angiolymphatic invasion was associated with APF+. In a
multivariate analysis, only tumors of ≤ 5 cm were significantly associated with EpCAM+ (OR = 8.7; 95%CI, 1.27-100.0; p = 0.022).
The overall survival rate was 74.9%, 69.4%, 69.4%, and 53.5% at 12, 24, 36, and 48 months, respectively. Conclusion. A considerable
number of patients with EpCAM+ HCC would benefit from a specific target therapy
Abstract
Assunto
Carderinas, alfa-Fetoproteínas, Carcinoma Hepatocelular
Palavras-chave
epithelial cell adhesion molecule, alpha-fetoprotein, Hepatocellular carcinoma
Citação
Curso
Endereço externo
https://www.hindawi.com/journals/cjgh/2018/5970852/