Immunohistochemical coexpression of epithelial cell adhesion molecule and alpha-fetoprotein in hepatocellular carcinoma

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dc.creatorLeonardo do Pradolima
dc.creatorCarla Jorge Machado
dc.creatorJoão Bernardo Sancio Rocha Rodrigues
dc.creatorLeonardo de Souza Vasconcellos
dc.creatorEduardo Paulino Junior
dc.creatorPaula Vieira Teixeira Vidigal
dc.creatorVivian Resende
dc.date.accessioned2023-06-19T20:53:54Z
dc.date.accessioned2025-09-09T00:12:59Z
dc.date.available2023-06-19T20:53:54Z
dc.date.issued2018-07-19
dc.format.mimetypepdf
dc.identifier.doi10.1155/2018/5970852
dc.identifier.issn22912797
dc.identifier.urihttps://hdl.handle.net/1843/55134
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCanadian Journal of Gastroenterology and Hepatology
dc.rightsAcesso Aberto
dc.subjectCarderinas
dc.subjectalfa-Fetoproteínas
dc.subjectCarcinoma Hepatocelular
dc.subject.otherepithelial cell adhesion molecule
dc.subject.otheralpha-fetoprotein
dc.subject.otherHepatocellular carcinoma
dc.titleImmunohistochemical coexpression of epithelial cell adhesion molecule and alpha-fetoprotein in hepatocellular carcinoma
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume2018
local.description.resumoBackground and Aim. The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association with clinicopathological characteristics. Methods. This study included Child-Pugh A HCC patients undergoing curative surgical resection. Results. A significant difference was observed in the ratio between the different phenotypes (p = 0.002), identifying 12 (29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors. EpCAM+ expression was associated with AFP + (OR = 12.5, 95% CI, 1.9-84.1, p<0.001). In univariate analysis, a significant association was observed between AFP+ and EPCAM+ and the serum AFP level. A diameter of ≤ 5 cm was associated with EPCAM+, while angiolymphatic invasion was associated with APF+. In a multivariate analysis, only tumors of ≤ 5 cm were significantly associated with EpCAM+ (OR = 8.7; 95%CI, 1.27-100.0; p = 0.022). The overall survival rate was 74.9%, 69.4%, 69.4%, and 53.5% at 12, 24, 36, and 48 months, respectively. Conclusion. A considerable number of patients with EpCAM+ HCC would benefit from a specific target therapy
local.identifier.orcidhttps://orcid.org/0000-0001-6157-6511
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://www.hindawi.com/journals/cjgh/2018/5970852/

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