Avaliação dos níveis urinários de citocinas e quimiocinas em crianças e adolescentes portadores de doença renal crônica

Abstract

Chronic Kidney Disease (CKD) is a serious public health problem whose prevalence has increased in the last few years. Its progression is associated with high morbidity and mortality. Several factors are associated with the onset and progression of CKD, such as obesity, hypertension and diabetes mellitus. Beyond these factors, there is evidence of inflammation in the pathophysiology of CKD. Several cytokines and chemokines have been detected in plasma and urine of patients at early stages of CKD as well as were related to CKD complications. The expression of these mediators and renal injury may be influenced by drugs such as angiotensin converting enzyme inhibitors, statins and antagonists of cytokine receptors. The modulation of immune-inflammatory response can become a target for the treatment of CKD. The aim of this dissertation was to conduct a detailed study of the inflammatory profile of chronic kidney disease in the pediatric population with this condiction, treated at a tertiary service in Belo Horizonte, as well as to perform a systematic review and summarize the scientific evidence of the role of inflammation in CKD, highlighting the effects of cytokines and chemokines.