The participation of tumor residing pericytes in oral squamous cell carcinoma

Página do item simplificado
dc.creatorIsabella Bittencourt do Valle
dc.creatorGabriel da Silva
dc.creatorAndréia Machado Leopoldino
dc.creatorSoraia Macari
dc.creatorAlexander Birbrair
dc.creatorSandra Ventorin von Zeidler
dc.creatorIvana Márcia Alves Diniz
dc.creatorTarcília Aparecida da Silva
dc.creatorSicília Rezende Oliveira
dc.creatorJanine Mayra da Silva
dc.creatorGabriela Tonini Peterle
dc.creatorAnna Clara Gregório Có
dc.creatorSebastião Silvério Sousa-Neto
dc.creatorElismauro Francisco Mendonça
dc.creatorJosé Alcides Almeida de Arruda
dc.creatorNatália Aparecida Gomes
dc.date.accessioned2025-05-15T19:46:00Z
dc.date.accessioned2025-09-08T23:08:59Z
dc.date.available2025-05-15T19:46:00Z
dc.date.issued2023
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41598-023-32528-1
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/82315
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific reports
dc.rightsAcesso Aberto
dc.subjectNeoplasms
dc.subjectPericytes
dc.subjectMouth neoplasms
dc.subjectCarcinogenesis
dc.subjectGene expression
dc.subjectProteins
dc.subjectSurvival
dc.subjectRNA, messenger
dc.subjectPlatelet endothelial cell adhesion molecule-1
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectLeukoplakia, oral
dc.subjectEvaluation study
dc.subjectReceptor, platelet-derived growth factor beta
dc.subjectNestin
dc.subjectVon Willebrand factor
dc.subject.otherOral cancer
dc.subject.otherCancer
dc.titleThe participation of tumor residing pericytes in oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage15
local.citation.issue5460
local.citation.spage1
local.citation.volume13
local.description.resumoPericytes are perivascular cells related to vessel structure and angiogenesis that can interact with neoplastic cells, interfering with cancer progression and outcomes. This study focused on the characterization of pericytes in oral squamous cell carcinoma (OSCC) using clinical samples and a transgenic mouse model of oral carcinogenesis. Nestin-/NG2+ (type-1) and nestin+/NG2+ (type-2) pericytes were analyzed by direct fluorescence after induction of oral carcinogenesis (4-nitroquinoline-1-oxide). Gene expression of neuron glial antigen-2 (NG2), platelet-derived growth factor receptor beta (PDGFR-β), and cluster of differentiation 31 (CD31) was examined in human OSCC tissues. The protein expression of von Willebrand factor and NG2 was assessed in oral leukoplakia (i.e., oral potentially malignant disorders) and OSCC samples. Additionally, clinicopathological aspects and survival data were correlated and validated by bioinformatics using The Cancer Genome Atlas (TCGA). Induction of carcinogenesis in mice produced an increase in both NG2+ pericyte subsets. In human OSCC, advanced-stage tumors showed a significant reduction in CD31 mRNA and von Willebrand factor-positive vessels. Low PDGFR-β expression was related to a shorter disease-free survival time, while NG2 mRNA overexpression was associated with a reduction in overall survival, consistent with the TCGA data. Herein, oral carcinogenesis resulted in an increase in NG2+ pericytes, which negatively affected survival outcomes.
local.identifier.orcidhttps://orcid.org/0000-0002-3221-3057
local.identifier.orcidhttps://orcid.org/0000-0002-8313-4754
local.identifier.orcidhttps://orcid.org/0000-0001-7643-6589
local.identifier.orcidhttps://orcid.org/0000-0003-1015-2561
local.identifier.orcidhttps://orcid.org/0000-0002-8897-5747
local.identifier.orcidhttps://orcid.org/0000-0003-4261-0037
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-8164-2122
local.identifier.orcidhttps://orcid.org/0000-0002-1473-7455
local.identifier.orcidhttps://orcid.org/0000-0001-7735-936X
local.identifier.orcidhttps://orcid.org/0000-0002-7737-0371
local.identifier.orcidhttps://orcid.org/0000-0001-8890-8723
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.identifier.orcidhttps://orcid.org/0000-0002-6599-3950
local.identifier.orcidhttps://orcid.org/0000-0001-6316-4713
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-023-32528-1

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
The participation of tumor residing pericytes in oral squamous cell carcinoma.pdf
Tamanho:
11.69 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG