Dysarthria in hereditary spastic paraplegia type 4
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Objective: To describe the speech pattern of patients with hereditary Spastic Paraplegia type 4 (SPG4) and correlated
it with their clinical data.
Methods: Cross-sectional study was carried out in two university hospitals in Brazil. Two groups participated in the
study: the case group (n = 28) with a confirmed genetic diagnosis for SPG4 and a control group (n = 17) matched
for sex and age. The speech assessment of both groups included: speech task recording, acoustic analysis, and auditory-
perceptual analysis. In addition, disease severity was assessed with the Spastic Paraplegia Rating Scale (SPRS).
Results: In the auditory-perceptual analysis, 53.5% (n = 15) of individuals with SPG4 were dysarthric, with mild
to moderate changes in the subsystems of phonation and articulation. On acoustic analysis, SPG4 subjects’ performances
were worse in measurements related to breathing (maximum phonation time) and articulation (speech
rate, articulation rate). The articulation variables (speech rate, articulation rate) are related to the age of onset of
the first motor symptom.
Conclusion: Dysarthria in SPG4 is frequent and mild, and it did not evolve in conjunction with more advanced
motor diseases. This data suggest that diagnosed patients should be screened and referred for speech therapy evaluation
and those pathophysiological mechanisms of speech involvement may differ from the length-dependent
degeneration of the corticospinal tract.
Abstract
Assunto
Distúrbios da fala, Distúrbios da articulação
Palavras-chave
Spastic Paraplegia, Hereditary, Dysarthria, Speech, Speech Disorders
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Endereço externo
https://www.sciencedirect.com/science/article/pii/S1807593222033294