Dysarthria in hereditary spastic paraplegia type 4

Página do item simplificado
dc.creatorLais Alves Jacinto-Scudeiro
dc.creatorRui Rothe-Neves
dc.creatorVanessa Brzoskowski dos Santos
dc.creatorGustavo Dariva Machado
dc.creatorDaniela Burguêz
dc.creatorMarina Martins Pereira Padovani
dc.creatorAnnelise Ayres
dc.creatorRafaela Soares Rech
dc.creatorCarelis González-Salazar
dc.creatorMarcondes Cavalcante França Junior
dc.creatorJonas Alex Morales Saute
dc.creatorMaira Rozenfeld Olchik
dc.date.accessioned2024-11-26T15:14:16Z
dc.date.accessioned2025-09-09T00:04:58Z
dc.date.available2024-11-26T15:14:16Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.clinsp.2022.100128
dc.identifier.issn1980-5322
dc.identifier.urihttps://hdl.handle.net/1843/78293
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinics
dc.rightsAcesso Aberto
dc.subjectDistúrbios da fala
dc.subjectDistúrbios da articulação
dc.subject.otherSpastic Paraplegia, Hereditary
dc.subject.otherDysarthria
dc.subject.otherSpeech
dc.subject.otherSpeech Disorders
dc.titleDysarthria in hereditary spastic paraplegia type 4
dc.typeArtigo de periódico
local.citation.volume78
local.description.resumoObjective: To describe the speech pattern of patients with hereditary Spastic Paraplegia type 4 (SPG4) and correlated it with their clinical data. Methods: Cross-sectional study was carried out in two university hospitals in Brazil. Two groups participated in the study: the case group (n = 28) with a confirmed genetic diagnosis for SPG4 and a control group (n = 17) matched for sex and age. The speech assessment of both groups included: speech task recording, acoustic analysis, and auditory- perceptual analysis. In addition, disease severity was assessed with the Spastic Paraplegia Rating Scale (SPRS). Results: In the auditory-perceptual analysis, 53.5% (n = 15) of individuals with SPG4 were dysarthric, with mild to moderate changes in the subsystems of phonation and articulation. On acoustic analysis, SPG4 subjects’ performances were worse in measurements related to breathing (maximum phonation time) and articulation (speech rate, articulation rate). The articulation variables (speech rate, articulation rate) are related to the age of onset of the first motor symptom. Conclusion: Dysarthria in SPG4 is frequent and mild, and it did not evolve in conjunction with more advanced motor diseases. This data suggest that diagnosed patients should be screened and referred for speech therapy evaluation and those pathophysiological mechanisms of speech involvement may differ from the length-dependent degeneration of the corticospinal tract.
local.identifier.orcidhttps://orcid.org/0000-0002-8896-8862
local.identifier.orcidhttps://orcid.org/0000-0002-2322-3499
local.identifier.orcidhttps://orcid.org/0000-0003-3388-3666
local.identifier.orcidhttps://orcid.org/0000-0001-9120-6562
local.identifier.orcidhttps://orcid.org/0000-0003-3205-3660
local.identifier.orcidhttps://orcid.org/0000-0002-3207-0180
local.identifier.orcidhttps://orcid.org/0000-0003-2300-682X
local.identifier.orcidhttps://orcid.org/0000-0003-0898-2419
local.identifier.orcidhttps://orcid.org/0000-0003-1141-6573
local.identifier.orcidhttps://orcid.org/0000-0002-8732-9225
local.publisher.countryBrasil
local.publisher.departmentFALE - FACULDADE DE LETRAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1807593222033294

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Dysarthria in hereditary spastic paraplegia type 4.pdf
Tamanho:
256.2 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG