Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Background: diet macronutrient heterogeneity hinders animal studies' data extrapolation from metabolic disorders to human diseases.
Objective: the present study aimed to evaluate different fat-diet compositions' effect on inducing lipid/glucose metabolism alterations in mice. Methods: swiss male mice were fed for 12 weeks with five different diets: Standard Diet (ST), American Institute of Nutrition 93 for growth (AIN93G) high-butter/high-sugar (HBHS), high-lard/high-sugar (HLHS), and high-oil/high-sugar diet (soybean oil) (HOHS). Several parameters, such as serum biochemistry, histology, and liver mRNA expression, were accessed. Results: the main findings revealed that the HLHS diet dramatically altered liver metabolism inducing hepatic steatosis and increased total cholesterol, triglycerides, VLDL, increasing liver CCAAT/enhancer binding protein (CEBP-α), Acetyl-CoA carboxylase (ACC) and Catalase (CAT) mRNA expression. Moreover, the HLHS diet increased glucose intolerance and reduced insulin sensitivity. Conclusions: high-fat/high-sugar diets are efficient to induce obesity and metabolic syndrome-associated alterations, and diets enriched with lard and sugar showed more effective results.
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Obesidade, Síndrome metabólica, Stress oxidativo, Hiperglicemia, Esteatose hepática, Açúcar no organismo
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https://www.tandfonline.com/doi/abs/10.1080/13813455.2020.1835986?journalCode=iarp20