Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model

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dc.creatorVictor Hugo Dantas Guimarães
dc.creatorDeborah de Farias Lelis
dc.creatorLuís Paulo Oliveira
dc.creatorLuciana Mendes Araújo Borém
dc.creatorFelipe Alberto Dantas Guimarães
dc.creatorLucyana Conceição Farias
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2022-09-08T15:30:45Z
dc.date.accessioned2025-09-08T23:41:29Z
dc.date.available2022-09-08T15:30:45Z
dc.date.issued2020-11-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1080/13813455.2020.1835986
dc.identifier.issn1744-4160
dc.identifier.urihttps://hdl.handle.net/1843/45005
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.rightsAcesso Restrito
dc.subjectObesidade
dc.subjectSíndrome metabólica
dc.subjectStress oxidativo
dc.subjectHiperglicemia
dc.subjectEsteatose hepática
dc.subjectAçúcar no organismo
dc.titleComparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model
dc.typeArtigo de periódico
local.citation.epage11
local.citation.spage1
local.description.resumoBackground: diet macronutrient heterogeneity hinders animal studies' data extrapolation from metabolic disorders to human diseases. Objective: the present study aimed to evaluate different fat-diet compositions' effect on inducing lipid/glucose metabolism alterations in mice. Methods: swiss male mice were fed for 12 weeks with five different diets: Standard Diet (ST), American Institute of Nutrition 93 for growth (AIN93G) high-butter/high-sugar (HBHS), high-lard/high-sugar (HLHS), and high-oil/high-sugar diet (soybean oil) (HOHS). Several parameters, such as serum biochemistry, histology, and liver mRNA expression, were accessed. Results: the main findings revealed that the HLHS diet dramatically altered liver metabolism inducing hepatic steatosis and increased total cholesterol, triglycerides, VLDL, increasing liver CCAAT/enhancer binding protein (CEBP-α), Acetyl-CoA carboxylase (ACC) and Catalase (CAT) mRNA expression. Moreover, the HLHS diet increased glucose intolerance and reduced insulin sensitivity. Conclusions: high-fat/high-sugar diets are efficient to induce obesity and metabolic syndrome-associated alterations, and diets enriched with lard and sugar showed more effective results.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/abs/10.1080/13813455.2020.1835986?journalCode=iarp20

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