Merkel cell carcinoma of the lower lip: a case report and literature review
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Universidade Federal de Minas Gerais
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Artigo de periódico
Título alternativo
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Membros da banca
Resumo
Merkel cell carcinoma (MCC) is an aggressive primary cutaneous neuroendocrine carcinoma that predominantly
affects the sun-damaged skin of the head and neck region, extremities, and trunk of white older individuals.
Microscopically, small to intermediate round blue cells show granular nuclei with a salt-and-pepper chromatin
pattern, and are usually positive for epithelial and neuroendocrine markers, particularly for cytokeratin 20 in a
perinuclear dot-like staining. The 5-year overall survival rate for individuals with localized MCC is 51% and the
most common treatment choice is surgery with adjuvant radiotherapy. As far as we know, 23 cases of MCC of the
lips have been reported to date in the English-language literature. We herein contribute by reporting a case of
MCC affecting the lower lip of an 81-year-old male patient from Rio de Janeiro, Brazil, which likely represents
the first reported case from Latin America. A review of the current literature is also included in an effort to
familiarize providers with this rare, but potentially lethal neuroendocrine tumor.
Abstract
Assunto
Lip, Carcinoma, merkel cell, Mouth neoplasms, Mouth mucosa, Ultraviolet rays, Keratins, Carcinoma, neuroendocrine, Surgical oncology, Radiotherapy
Palavras-chave
Lip, Merkel cell carcinoma, Oral cancer, Oral mucosa, Oral oncology, UV light
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https://www.sciencedirect.com/science/article/abs/pii/S1368837520304553