Merkel cell carcinoma of the lower lip: a case report and literature review

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dc.creatorJosé Alcides Almeida de Arruda
dc.creatorRicardo Alves de Mesquita
dc.creatorNathalie Henriques Silva Canedo
dc.creatorMichelle Agostini
dc.creatorAline Corrêa Abrahão
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorMário José Romañach
dc.date.accessioned2024-10-31T13:28:26Z
dc.date.accessioned2025-09-09T01:15:46Z
dc.date.available2024-10-31T13:28:26Z
dc.date.issued2021-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2020.105019
dc.identifier.issn1879-0593
dc.identifier.urihttps://hdl.handle.net/1843/77750
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Oncology
dc.rightsAcesso Restrito
dc.subjectLip
dc.subjectCarcinoma, merkel cell
dc.subjectMouth neoplasms
dc.subjectMouth mucosa
dc.subjectUltraviolet rays
dc.subjectKeratins
dc.subjectCarcinoma, neuroendocrine
dc.subjectSurgical oncology
dc.subjectRadiotherapy
dc.subject.otherLip
dc.subject.otherMerkel cell carcinoma
dc.subject.otherOral cancer
dc.subject.otherOral mucosa
dc.subject.otherOral oncology
dc.subject.otherUV light
dc.titleMerkel cell carcinoma of the lower lip: a case report and literature review
dc.typeArtigo de periódico
local.citation.spage105019
local.citation.volume113
local.description.resumoMerkel cell carcinoma (MCC) is an aggressive primary cutaneous neuroendocrine carcinoma that predominantly affects the sun-damaged skin of the head and neck region, extremities, and trunk of white older individuals. Microscopically, small to intermediate round blue cells show granular nuclei with a salt-and-pepper chromatin pattern, and are usually positive for epithelial and neuroendocrine markers, particularly for cytokeratin 20 in a perinuclear dot-like staining. The 5-year overall survival rate for individuals with localized MCC is 51% and the most common treatment choice is surgery with adjuvant radiotherapy. As far as we know, 23 cases of MCC of the lips have been reported to date in the English-language literature. We herein contribute by reporting a case of MCC affecting the lower lip of an 81-year-old male patient from Rio de Janeiro, Brazil, which likely represents the first reported case from Latin America. A review of the current literature is also included in an effort to familiarize providers with this rare, but potentially lethal neuroendocrine tumor.
local.identifier.orcidhttps://orcid.org/0000-0002-6599-3950
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.identifier.orcidhttps://orcid.org/0000-0002-3648-337X
local.identifier.orcidhttps://orcid.org/0000-0002-3397-3234
local.identifier.orcidhttps://orcid.org/0000-0002-3259-606X
local.identifier.orcidhttps://orcid.org/0000-0002-7853-5916
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S1368837520304553

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