Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
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Universidade Federal de Minas Gerais
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Artigo de periódico
Título alternativo
Terapia hormonal após cirurgia redutora de risco em pacientes com mutação BRCA1/BRCA2: evidências dos benefícios potenciais e segurança
Primeiro orientador
Membros da banca
Resumo
Women with mutations in the BRCA 1 and 2 genes are at increased risk for ovarian and breast cancer and therefore candidates for
risk-reducing surgery, including salpingo-oophorectomy and mastectomy. Risk-reducing salpingo-oophorectomy (RRSO) is considered
the most effective prophylactic measure for ovarian cancer prevention in this group of patients. This procedure involves loss of ovarian
function and induced menopause. Estrogen therapy is the most effective treatment for controlling vasomotor symptoms and improving
the quality of life of climacteric women. However, the potential hormonal stimulation of these tumors and the risk of breast cancer are a
concern regarding the safety of hormone replacement therapy (HRT) in this population. This article aims to review the current evidence
regarding the potential benefits and safety of HRT after RRSO.
Abstract
Assunto
Mutação, Terapia de reposição de estrogênios, Salpingostomia, Ovariectomia, Salpingo-ooforectomia, Neoplasias da mama
Palavras-chave
Mutation, Estrogen replacement therapy, Salpingostomy, Ovariectomy, Salpingo-oophorectomy, Breast neoplasms
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Endereço externo
https://www.scielo.br/j/ramb/a/cxBbmG4y5NQmftjqfQddWdk/?format=html&lang=en