Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety

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dc.creatorAgnaldo Lopes da Silva Filho
dc.creatorEduardo Batista Cândido
dc.creatorGabriella Martins Carvalho
dc.creatorLarissa Cristelli de Sena
dc.creatorLívia Passini Guimarães Gomes
dc.creatorMarcos Flávio Habib Valério
dc.creatorRaíssa Isabelle Leão Martins
dc.date.accessioned2023-05-05T20:48:44Z
dc.date.accessioned2025-09-09T01:25:49Z
dc.date.available2023-05-05T20:48:44Z
dc.date.issued2020-08
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1806-9282.66.8.1134
dc.identifier.issn1806-9282
dc.identifier.urihttps://hdl.handle.net/1843/52883
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista da Associação Médica Brasileira
dc.rightsAcesso Aberto
dc.subjectMutação
dc.subjectTerapia de reposição de estrogênios
dc.subjectSalpingostomia
dc.subjectOvariectomia
dc.subjectSalpingo-ooforectomia
dc.subjectNeoplasias da mama
dc.subject.otherMutation
dc.subject.otherEstrogen replacement therapy
dc.subject.otherSalpingostomy
dc.subject.otherOvariectomy
dc.subject.otherSalpingo-oophorectomy
dc.subject.otherBreast neoplasms
dc.titleHormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
dc.title.alternativeTerapia hormonal após cirurgia redutora de risco em pacientes com mutação BRCA1/BRCA2: evidências dos benefícios potenciais e segurança
dc.typeArtigo de periódico
local.citation.epage1138
local.citation.issue8
local.citation.spage1134
local.citation.volume66
local.description.resumoWomen with mutations in the BRCA 1 and 2 genes are at increased risk for ovarian and breast cancer and therefore candidates for risk-reducing surgery, including salpingo-oophorectomy and mastectomy. Risk-reducing salpingo-oophorectomy (RRSO) is considered the most effective prophylactic measure for ovarian cancer prevention in this group of patients. This procedure involves loss of ovarian function and induced menopause. Estrogen therapy is the most effective treatment for controlling vasomotor symptoms and improving the quality of life of climacteric women. However, the potential hormonal stimulation of these tumors and the risk of breast cancer are a concern regarding the safety of hormone replacement therapy (HRT) in this population. This article aims to review the current evidence regarding the potential benefits and safety of HRT after RRSO.
local.identifier.orcidhttps://orcid.org/0000-0002-8486-7861
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/ramb/a/cxBbmG4y5NQmftjqfQddWdk/?format=html&lang=en

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