Estudo fitoquímico de aristolochia esperanzae kuntze (Aristolochiaceae)

Abstract

Most of the rheumatic diseases in the Minas Gerais são popularmente tratadas com o uso de Aristolochia esperanzae.region involve the treatment using Aristolochia esperanzae. The literature records phytochemical studies of leaves and roots from A. esperanzae and this work describes the chromatographic isolation of stem bark and stem chemical constituents of this plant. The ethanolic stem bark extract presented aliphatic hydrocarbons, one lignan, two diterpenes, ristolochic acids and aristololactams. The ethanolic stem extract presented one cubebin, aristolochic acids and sitosterol-3- O-ß-D-glucopyranoside. Their complete structures have been establish mainly based on 2D NMRspectral HSQC, HMBC, NOESY and COSY. Compounds asarinin, populifolic acid, 2 oxo-populifolic acid, aristololactams AIa and AII and sitosterol-3-O-ß-D-glucopyranoside were first reports on thesespecies. The ethanolic stem bark and constituents asarinin (AE1) e (8R,8R,9S)-cubebin (AE2) were active towards Bacillus cereus.